Agreed that anything goes with non-matching cars. Then it comes down to quality and features rather than originality. But a 400 in any body brings more buyers, and usually more cash, than an equally nice 350 2 bbl matching car at present. The original 350s haven't hit the desirable status that commands $$ above condition. This will change.
As for modifying to meet the market, I think that in the long run the cars that are most original will see the biggest increase in value. Think of all the modified cars of the '80s that we have to "fix" to make original again, or re-modify to current modification standards.
But as former owner of an immaculate Sprint LeMans, I can attest to the fact that selling a prime numbers matching Sprint means hearing many people saying "if only it had a V-8"...
They just don't know what they are missing, and as the Sprint requires a special kind of owner (one who actually maintains a car, not just drives it until it breaks), I was not going to sell until I found someone who appreciated it for what is was and didn't plan to GTO-clone it. And although I got above top-dollar for the Sprint, it didn't hit the level of a 326 HO or 400 car.
I put 3,000 miles on my Sprint from July through October, and enjoyed every minute of it.
Vikki 1969 Goldenrod Yellow / black 400 convertible numbers matching