Q-Jet, Holley, Edelbrock all go about the same function in different ways. Wit that said they are all good in their own ways, but in most cases, the Quadrajet is a better choice as it's typically a more versatile in a wider range of conditions.
"Typically" better fuel economy, better CFM ratings, better reliability and once those large secondaries open to 90 degrees a bigger smile upon your face!
There are exceptions to every rule, and as Bjorn's friend Rolf Pointed out, most stick with what they know. For comparisons sake, I have tried multiple similar CFM rated carbs on my relatively stock 455 over the years (Edelbrock, Holley and Q-Jet) and they were all pretty much straight out of the box, just slight tuning. The Q-jet was by far my favorite. Especially on the MPG front...
I'm building a performance based Q-jet now using Cliff's carb kit and book as a guide. I'm actually surprised at how many little things you can do to really take a stock Q-Jet to the next level.
So anyone who is not a fan of the Q-Jet, please send them my way! I'll take all you got... and will even trade you a Holley or two...