That would be a 'Yes' and a real big PITA. If you don't care about originality I have seen that others use rivits.
I see they sell they staples now seperatly in the Ames catalog (I think). I had a few left over from the rubber flaps found in the engine compartment.
I clamped the weather striping down on the door panel and drilled new holes for the staples with a 1/16 bit. I think I broke 8 of them. It was tedious work.