1) get the carb you or someone you know can work on 2) Holley will waste more gas than the Q-Jet 3) I run a Holley because my buddy is good at working on them , see no 1, LOL) 4) a Holley 750 is way to big for a 400 imho, you`re wasting gas... a 650 is 'just right' , if its a Holley... I now run a holley 650 on my 400...
just a side note..I once had a Holley 650 on my Ford 302 in a Healey replica ( 1950 lbs fiberglass car), I got 12 mpg...changed to a 1850, I got 19 mpg and car was quicker! Bigger is not always better...the air wont be able to mix with all that gas...