I'm running a 428 .060 over with 6X-8 heads, a 750 Holly vacuum secondaries, and a 229/239 at .05" of lift cam. The cam is almost a little too obnoxious for everyday street driving, but I can run 91 octane gas. At the track, I've only run 14.1 in the 1/4, but that's with an open 3.08 rearend. I basically had no traction and posted horrid 60-ft times.
With a posi and slightly higher (numerical) gears, I'll easily get down into the 13s. With better exhaust (headers, x-pipe) and carb and timing tuning (haven't touched 'em), I dream of getting into the 12s. 12s are tough, though, so I may have to be content with dreaming...