The OP isn't talking about a race only application. Unless I'm misunderstanding his query, he's asking about a relatively stock rebuild, and how E85 will save the cost of more expensive modifications.

My point is that you're not gonna resolve the detonation and over heating that some of us have/had on our stock engines by switching to E85 you can get at a " regular" gas station. You'd have better luck going to the Abita Airport and filling up with low lead 100 (which I have...it's awesome! ...and smells a lot better.)

I think the OP building an engine without the normal modifications for modern fuels, thinking E85 will eliminate the need, would be foolish. That's not sticking your head in the sand. That's doing your homework and using common sense. No disrespect my Louisiana brother. I just don't agree with you.