Yup, its a pain. Not like just slapping a new one in or out. Those designers back in '68 really wanted that AM radio to be mounted like a TANK! It weighs as much as a new home stereo, so be careful.
I recall having to pull the bezel, the ashtray, and several support pieces. The connectors are idiot-proof, but hard to get out if they are 38 years old. Take your time, save ALL nuts and bolts for future projects. If you are pulling or replacing the dash center speaker, then the AC/Heat assembly needs to be loose. Thats a pain too, one that will make you punch a few concrete walls in anger!!!
BUT....take it easy. Relax. Enjoy!
'68 428 HO M3 Monster, 4-on-the-floor! Need I say more?