To further the commentary..Most guys do the swap for what I call "cool points" and without looking at the impact. Most 2 barrel cars, I guess have highway gears..mid 2's very low 3's maybe.

You put a huge carb on a motor. (whether or not you can tune a carb, irrelevant)

Brent brought up the point on a post about exhaust that a motor is an air pump..of course, it is. I'll break this fact down in sort of laymans terms. I will assign a number for each motor part within this air pump.

Carb, 4 barrel #7
Intake 4 barrel #7
Cam, 2 barrel #4
heads, 2 barrel #4
exhaust 2 barrel #4
rear gear 2 barrel #4
trans gearing #4 (maybe the same as a 4 barrel though)

The trans and exhaust size/configuration may be different for a 2 barrel car. Maybe they got single outlet or duals with smaller pipes over a 4 barrel car. I know my 96 TA 8 cylinder had duals and a 96 Firebird had a single outlet. The trans ratios may be different, but I really have not had my eyes in any big car or 2 barrel research.

Those numbers sort of (basically) reflect air flow in a motor. Why increase airflow at the top to only bottleneck or restrict airflow within the motor in theory. Will the motor run? sure it will. It is to what efficiency and temperment that it does.

Most 2 barrel heads have 1.96 heads and 1.66 exhaust. A great example is 1969 #47 heads (350) #48 heads (350HO and RAIII 400). The 47's are 72 CC 1.96/1.66 valves and press in studs. The #48 for a 350 are 65 CC and 2.11/1.77 screw in studs. The #48 400 heads are 2.11/1.77 72 cc and screw in studs. The 47's are 2 barrel heads, the #48's are 4 barrel. The difference between the two is intake/exhaust size and press/screw in studs. The 47's can be converted to 2.11/1.77 and tapped for screw in studs and you could have a set of RAIII heads. The machining costs to convert far outweigh locating the proper heads.

The 254 cam had a duration of 269/277 and that was used both on 350 and 400 motors with 2 barrels.

I may be blowing smoke, but..mismatched engine components will work, but at what overall effect?