Holley are a breeze to tune. Your 4160 vacuum secondary carb shouldn't need much. If you plan to stay in Colorado, you need to jet it properly. Two ways to do that, either read the plugs like was done for years, or buy a sniffer and test the exhaust gasses to determine air fuel ratio. My holley run about 12 to one when I'm on it, and close to 14.7 at cruise. You could always find a chassis dyno and b have them tune it. Of course if you are passing thru Colorado, I wouldn't change anything. The f/I cars all adjust on the fly, carbs require manual adjustments. Let me help you, that 4160 carb has a aluminum tube that connects the front fuel bowl to the rear. When you disassemble it, you will need a new oring on each end of that tube or it will leak. Have them before you disassemble the carb.