It all depends on what you want. The only time I've ever been disappointed in having too much compression is when I damaged an engine because I was too stubborn(stupid) to pay for the high octane fuel. In my book there are two rules when planning a build: 1. There's no replacement for displacement. 2. Except, maybe, compression.
Picture a new Caddy passing you with your pedal to the metal.... This will happen with low cubes and/or low compression. It will not with high cubes and/or high compression. I'll pay the extra for high octane. Because it's fun to have too much power!!!!